Overlooked potential of positrons in cancer therapy.

ABSTRACT: Positron (β⁺) emitting radionuclides have been used for positron emission tomography (PET) imaging in diagnostic medicine since its development in the 1950s. Development of a fluorinated glucose analog, fluorodeoxyglucose, labelled with a β⁺ emitter fluorine-18 (¹⁸F-FDG), made it possible to image cellular targets with high glycolytic metabolism. These targets include cancer cells based on increased aerobic metabolism due to the Warburg effect, and thus, ¹⁸F-FDG is a staple in nuclear medicine clinics globally. However, due to its attention in the diagnostic setting, the therapeutic potential of β⁺ emitters have been overlooked in cancer medicine. Here we show the first in vitro evidence of β⁺ emitter cytotoxicity on prostat

SUBMITTER: Hioki T 

PROVIDER: S-EPMC7843622 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature