Cymene consumption and physical activity effect in Alzheimer's disease model: an in vivo and in vitro study.

ABSTRACT:

Purpose

Alzheimer's disease (AD) is one of the most important neurodegenerative diseases and accompanied by the production of free radicals and inflammatory factors. Studies have shown that p-cymene has anti-inflammatory and anti-oxidant effects. Here, the effects of this compound were investigated on a rat model of AD.

Methods

In order to create Alzheimer's rat model, bilateral injection of Amyloid β1-42 (Aβ1-42) into rats hippocampus was performed. Both therapeutic (post-AD induction) and preventive effects of p-cymene consumption with doses of 50 and 100 mg/kg were investigated. In addition, the effects of adding short-term exercise to the process were also observed. In vitro, Aβ1-42 peptide was driven toward fibril formation and effect of p-cymene was observed on the res

SUBMITTER: Seifi-Nahavandi B 

PROVIDER: S-EPMC7843760 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature