Gene ontology enrichment analysis of α-amylase inhibitors from Duranta repens in diabetes mellitus.

ABSTRACT:

Background

Although α-amylase is the choice of target to manage postprandial hyperglycemia, inhibitors of this enzyme may get absorbed into the systemic circulation and modulate proteins involved in the pathogenesis of diabetes mellitus. Hence, the present study aimed to identify α-amylase inhibitors from Duranta repens via in silico and in vitro and predict their role in the modulation of multiple pathways involved in diabetes mellitus.

Methods

α-amylase inhibitory activity of hydroalcoholic extract/fractions (s) and pure compounds from D. repens was performed using in vitro enzyme inhibitory assay. Multiple open-source databases and published literature were used to retrieve reported phytoconstituents present in D. repens and their

SUBMITTER: Khanal P 

PROVIDER: S-EPMC7843765 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature