Involvement of Netrins and Their Receptors in Neuronal Migration in the Cerebral Cortex.

ABSTRACT: In mammals, excitatory cortical neurons develop from the proliferative epithelium and progenitor cells in the ventricular zone and subventricular zone, and migrate radially to the cortical plate, whereas inhibitory GABAergic interneurons are born in the ganglionic eminence and migrate tangentially. The migration of newly born cortical neurons is tightly regulated by both extracellular and intracellular signaling to ensure proper positioning and projections. Non-cell-autonomous extracellular molecules, such as growth factors, axon guidance molecules, extracellular matrix, and other ligands, play a role in cortical migration, either by acting as attractants or repellents. In this article, we review the guidance molecules that act as cell-cell recognition molecules for the regulation of neuro

SUBMITTER: Yamagishi S 

PROVIDER: S-EPMC7843923 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature