Atypical Neurogenesis in Induced Pluripotent Stem Cells From Autistic Individuals.

ABSTRACT:

Background

Autism is a heterogeneous collection of disorders with a complex molecular underpinning. Evidence from postmortem brain studies have indicated that early prenatal development may be altered in autism. Induced pluripotent stem cells (iPSCs) generated from individuals with autism with macrocephaly also indicate prenatal development as a critical period for this condition. But little is known about early altered cellular events during prenatal stages in autism.

Methods

iPSCs were generated from 9 unrelated individuals with autism without macrocephaly and with heterogeneous genetic backgrounds, and 6 typically developing control individuals. iPSCs were differentiated toward either cortical or midbrain fates. Gene expression and high throughput cellular phenotyping was

SUBMITTER: Adhya D 

PROVIDER: S-EPMC7843956 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature