Dynamics of Systemic Inflammation as a Function of Developmental Stage in Pediatric Acute Liver Failure.

ABSTRACT: The Pediatric Acute Liver Failure (PALF) study is a multicenter, observational cohort study of infants and children diagnosed with this complex clinical syndrome. Outcomes in PALF reflect interactions among the child's clinical condition, response to supportive care, disease severity, potential for recovery, and, if needed, availability of a suitable organ for liver transplantation (LTx). Previously, we used computational analyses of immune/inflammatory mediators that identified three distinct dynamic network patterns of systemic inflammation in PALF associated with spontaneous survivors, non-survivors (NS), and LTx recipients. To date, there are no data exploring age-specific immune/inflammatory responses in PALF. Accordingly, we measured a number of clinical characteristics and PALF-asso

SUBMITTER: Vodovotz Y 

PROVIDER: S-EPMC7844097 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature