The Therapeutic Potential of Regulatory T Cells: Challenges and Opportunities.

ABSTRACT: Regulatory T cells (Tregs) are an immunosuppressive subgroup of CD4⁺ T cells which are identified by the expression of forkhead box protein P3 (Foxp3). The modulation capacity of these immune cells holds an important role in both transplantation and the development of autoimmune diseases. These cells are the main mediators of self-tolerance and are essential for avoiding excessive immune reactions. Tregs play a key role in the induction of peripheral tolerance that can prevent autoimmunity, by protecting self-reactive lymphocytes from the immune reaction. In contrast to autoimmune responses, tumor cells exploit Tregs in order to prevent immune cell recognition and anti-tumor immune response during the carcinogenesis process. Recently, numerous studies have focused on unraveling

SUBMITTER: Bayati F 

PROVIDER: S-EPMC7844143 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature