Non pharmacological high-intensity ultrasound treatment of human dermal fibroblasts to accelerate wound healing.

ABSTRACT: Inspired by the effectiveness of low-intensity ultrasound on tissue regeneration, we investigated the potential effect of short-term high-intensity ultrasound treatment for acceleration of wound healing in an in vitro wound model and dermal equivalent, both comprising human dermal fibroblasts. Short-term ultrasound of various amplitudes significantly increased the proliferation and migration of fibroblasts and subsequently increased the production of the extracellular matrix components fibronectin and collagen type I, both of which are important for wound healing and are secreted by fibroblasts. In addition, ultrasound treatment increased the contraction of a fibroblast-embedded three-dimensional collagen matrix, and the effect was synergistically increased in the presence of TGF-β. RNA-se

SUBMITTER: Lee JY 

PROVIDER: S-EPMC7844265 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature