Meta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors.

ABSTRACT: A deeper understanding of the molecular biology of SARS-CoV-2 infection, including the host response to the virus, is urgently needed. Commonalities exist between the host immune response to viral infections and cancer. Here, we defined transcriptional signatures of SARS-CoV-2 infection involving hundreds of genes common across lung adenocarcinoma cell lines (A549, Calu-3) and normal human bronchial epithelial cells (NHBE), with additional signatures being specific to one or both adenocarcinoma lines. Cross-examining eight transcriptomic databases, we found that host transcriptional responses of lung adenocarcinoma cells to SARS-CoV-2 infection shared broad similarities with host responses to multiple viruses across different model systems and patient samples. Furthermore, these SARS-CoV-2

SUBMITTER: Chen F 

PROVIDER: S-EPMC7844278 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature