Identification of key genes and microRNA regulatory network in development and progression of urothelial bladder carcinoma.

ABSTRACT:

Background

Bladder cancer as other cancers contains multiple dynamic alterations in progression. Theoretically, large number of genes participates in cancer progression. In the present study, the interconnections of genesets defined by Gene Set Enrichment Analysis (GSEA) and tumor histopathological stages were characterized. In addition, the outcomes with genesets were discussed in bladder cancer.

Methods

Transcriptome data from 411 tissues of urothelial bladder carcinoma and 19 samples from adjacent tissues were retrieved from The Cancer Genome Atlas (TCGA) database. Single-sample GSEA (ssGSEA), cluster analysis of geneset enrichment scores and genesets as indicators in prognosis were applied to elucidate the correlations between genesets and bladder cancer progression.

SUBMITTER: Mo M 

PROVIDER: S-EPMC7844517 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature