Assessment of RAS Dependency for BRAF Alterations Using Cancer Genomic Databases.

ABSTRACT:

Importance

Understanding RAS dependency and mechanisms of RAS activation in non-V600 BRAF variant cancers has important clinical implications. This is the first study to date to systematically assess RAS dependency of BRAF alterations with real-world cancer genomic databases.

Objective

To evaluate RAS dependency of individual BRAF alterations through alteration coexistence analysis using cancer genomic databases.

Design and setting

A cross-sectional data analysis of 119 538 nonredundant cancer samples using cancer genomics databases including GENIE (Genomics Evidence Neoplasia Information Exchange) and databases in cBioPortal including TCGA (The Cancer Genome Atlas) (accessed March 24, 2020), in addition to 2745 cancer samples from Mayo Clinic Genomics Laboratory (Jan

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC7844594 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature