Prenatal particulate air pollution and newborn telomere length: Effect modification by maternal antioxidant intakes and infant sex.

ABSTRACT:

Background

Evidence links gestational exposure to particulate matter with an aerodynamic diameter of less than 2.5 μm (PM_2.5) with changes in leukocyte telomere length in cord blood with some studies showing sex-specific effects. PM_2.5 exposure in utero increases oxidative stress, which can impact telomere biology. Thus, maternal antioxidant intakes may also modify the particulate air pollution effects.

Methods

We examined associations among prenatal PM_2.5 exposure and newborn relative leukocyte telomere length (rLTL), and the modifying effects of maternal antioxidant intake and infant sex. We estimated daily PM_2.5 exposures over gestation using a validated spatiotemporally resolved satellite-based model. Maternal dietary and suppl

SUBMITTER: Lee AG 

PROVIDER: S-EPMC7844769 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature