Ceftiofur reduced Fusobacterium leading to uterine microbiota alteration in dairy cows with metritis.

ABSTRACT:

Background

Metritis is an inflammatory uterine disease found in ~ 20% of dairy cows after parturition and associated with uterine microbiota with high abundance of Fusobacterium, Bacteroides, and Porphyromonas. Ceftiofur is a common treatment, but the effect on uterine microbiota is poorly understood. Herein, we investigated the short-term impact of ceftiofur on uterine microbiota structure and function in cows with metritis. Eight cows received ceftiofur (CEF) and 10 remained untreated (CON). Uterine swabs were collected for PCR and metagenomic analysis at diagnosis before treatment (5 ± 1 DPP) and 2 days after diagnosis/treatment (7 ± 1 DPP) from the same individuals. Seven CEF and 9 CON passed quality control and were used for 16S rRNA gene sequencing.

Results

Ceftiofur t

SUBMITTER: Jeon SJ 

PROVIDER: S-EPMC7844903 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature