PeakMatcher facilitates updated Aedes aegypti embryonic cis-regulatory element map.

ABSTRACT:

Background

The Aedes aegypti mosquito is a threat to human health across the globe. The A. aegypti genome was recently re-sequenced and re-assembled. Due to a combination of long-read PacBio and Hi-C sequencing, the AaegL5 assembly is chromosome complete and significantly improves the assembly in key areas such as the M/m sex-determining locus. Release of the updated genome assembly has precipitated the need to reprocess historical functional genomic data sets, including cis-regulatory element (CRE) maps that had previously been generated for A. aegypti.

Results

We re-processed and re-analyzed the A. aegypti whole embryo FAIRE seq data to create an updated embryonic CRE map for the AaegL5 genome. We validated that the new CRE map recapitulates key features of the original Aa

SUBMITTER: Nowling RJ 

PROVIDER: S-EPMC7844911 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature