Evolutionary conservation and divergence of the human brain transcriptome.

ABSTRACT:

Background

Mouse models have allowed for the direct interrogation of genetic effects on molecular, physiological, and behavioral brain phenotypes. However, it is unknown to what extent neurological or psychiatric traits may be human- or primate-specific and therefore which components can be faithfully recapitulated in mouse models.

Results

We compare conservation of co-expression in 116 independent data sets derived from human, mouse, and non-human primate representing more than 15,000 total samples. We observe greater changes occurring on the human lineage than mouse, and substantial regional variation that highlights cerebral cortex as the most diverged region. Glia, notably microglia, astrocytes, and oligodendrocytes are the most divergent cell type, three times more on a

SUBMITTER: Pembroke WG 

PROVIDER: S-EPMC7844938 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature