Extracellular vesicles shed from gastric cancer mediate protumor macrophage differentiation.

ABSTRACT:

Background

Peritoneal dissemination often develops in gastric cancer. Tumor-associated macrophages (TAMs) are present in the peritoneal cavity of gastric cancer patients with peritoneal dissemination, facilitating tumor progression. However, the mechanism by which macrophages differentiate into tumor-associated macrophages in the peritoneal cavity is not well understood. In this study, the interplay between gastric cancer-derived extracellular vesicles (EVs) and macrophages was investigated.

Methods

The association between macrophages and EVs in peritoneal ascitic fluid of gastric cancer patients, or from gastric cancer cell lines was examined, and their roles in differentiation of macrophages and potentiation of the malignancy of gastric cancer were further explored.

Res

SUBMITTER: Ito A 

PROVIDER: S-EPMC7845052 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature