Potential effect modification of RTS,S/AS01 malaria vaccine efficacy by household socio-economic status.

ABSTRACT:

Background

In the phase III RTS,S /AS01 trial, significant heterogeneity in efficacy of the vaccine across study sites was seen. Question on whether variations in socio - economic status (SES) of participant contributed to the heterogeinity of the vaccine efficacy (VE) remains unknown.

Methods

Data from the Phase III RTS,S /AS01 trial in children aged 5-17 months in Kintampo were re-analysed. SES of each child was derived from the Kintampo Health and Demographic Surveillance System, using principal component analysis of household assets. Extended Cox regression was used to estimate the interaction between RTS,S/AS01 VE and household SES.

Results

Protective efficacy of the RTS,S/AS0 vaccine significantly varied by participant's household SES, thus increase in household

SUBMITTER: Gyaase S 

PROVIDER: S-EPMC7845116 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature