Cerebrospinal fluid biomarkers of neuroinflammation in children with hydrocephalus and shunt malfunction.

ABSTRACT:

Background

Approximately 30% of cerebrospinal fluid (CSF) shunt systems for hydrocephalus fail within the first year and 98% of all patients will have shunt failure in their lifetime. Obstruction remains the most common reason for shunt failure. Previous evidence suggests elevated pro-inflammatory cytokines in CSF are associated with worsening clinical outcomes in neuroinflammatory diseases. The aim of this study was to determine whether cytokines and matrix metalloproteinases (MMPs) contribute towards shunt failure in hydrocephalus.

Methods

Using multiplex ELISA, this study examined shunt failure through the CSF protein concentration profiles of select pro-inflammatory and anti-inflammatory cytokines, as well as select MMPs. Interdependencies such as the past number of prev

SUBMITTER: Harris CA 

PROVIDER: S-EPMC7845119 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature