Change in the plasma proteome associated with canine cognitive dysfunction syndrome (CCDS) in Thailand.

ABSTRACT:

Background

Canine cognitive dysfunction syndrome (CCDS) is a progressive neurodegenerative disorder found in senior dogs. Due to the lack of biological markers, CCDS is commonly underdiagnosed. The aim of this study was to identify potential plasma biomarkers using proteomics techniques and to increase our understanding of the pathogenic mechanism of the disease. Plasma amyloid beta 42 (Aβ₄₂) has been seen to be a controversial biomarker for CCDS. Proteomics analysis was performed for protein identification and quantification.

Results

Within CCDS, ageing, and adult dogs, 87 proteins were identified specific to Canis spp. in the plasma samples. Of 87 proteins, 48 and 41 proteins were changed in the ageing and adult groups, respectively. Several distinctly expressed

SUBMITTER: Phochantachinda S 

PROVIDER: S-EPMC7845120 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature