Transcriptome annotation in the cloud: complexity, best practices, and cost.

ABSTRACT:

Background

The NIH Science and Technology Research Infrastructure for Discovery, Experimentation, and Sustainability (STRIDES) initiative provides NIH-funded researchers cost-effective access to commercial cloud providers, such as Amazon Web Services (AWS) and Google Cloud Platform (GCP). These cloud providers represent an alternative for the execution of large computational biology experiments like transcriptome annotation, which is a complex analytical process that requires the interrogation of multiple biological databases with several advanced computational tools. The core components of annotation pipelines published since 2012 are BLAST sequence alignments using annotated databases of both nucleotide or protein sequences almost exclusively with networked on-premises compute sy

SUBMITTER: Alvarez RV 

PROVIDER: S-EPMC7845158 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature