Vitamin D, pre-eclampsia, and preterm birth among pregnancies at high risk for pre-eclampsia: an analysis of data from a low-dose aspirin trial.

ABSTRACT:

Objective

To examine the relation between maternal vitamin D status and risk of pre-eclampsia and preterm birth in women at high risk for pre-eclampsia.

Design

Analysis of prospectively collected data and blood samples from a trial of prenatal low-dose aspirin.

Setting

Thirteen sites across the USA.

Population

Women at high risk for pre-eclampsia.

Methods

We measured 25-hydroxyvitamin D [25(OH)D] concentrations in stored maternal serum samples drawn at 12-26 weeks' gestation (n = 822). We used mixed effects models to examine the association between 25(OH)D and risk of pre-eclampsia and preterm birth, controlling for confounders including prepregnancy BMI and race.

Main outcome measures

Pre-eclampsia and preterm birth.

Results

Twelve percent

SUBMITTER: Gernand AD 

PROVIDER: S-EPMC7845451 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature