Age-related abnormalities of thalamic shape and dynamic functional connectivity after three hours of sleep restriction.

ABSTRACT:

Background

Previous neuroimaging studies have detected abnormal activation and intrinsic functional connectivity of the thalamus after total sleep deprivation. However, very few studies have investigated age-related changes in the dynamic functional connectivity of the thalamus and the abnormalities in the thalamic shape following partial sleep deprivation.

Methods

Fifty-five participants consisting of 23 old adults (mean age: 68.8 years) and 32 young adults (mean age: 23.5 years) were included in current study. A vertex-based shape analysis and a dynamic functional connectivity analysis were used to evaluate the age-dependent structural and functional abnormalities after three hours of sleep restriction.

Results

Shape analysis revealed the significant main effect of

SUBMITTER: Long Z 

PROVIDER: S-EPMC7845526 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature