Changes in the brain transcriptome after DNA Aβ42 trimer immunization in a 3xTg-AD mouse model.

ABSTRACT: Alzheimer's disease (AD) has been associated with accumulation of amyloid beta (Aβ) peptides in brain, and immunotherapy targeting Aβ provides potential for AD prevention. We have used a DNA Aβ42 trimer construct for immunization of 3xTg-AD mice and found previously significant reduction of amyloid and tau pathology due to the immunotherapy. We show here that DNA Aβ42 immunized 3xTg-AD mice showed better performance in nest building activities and had a higher 24 months survival rate compared to the non-treated AD controls. The analysis of differently expressed genes in brains from 24 months old mice showed significant increases transcript levels between non-immunized AD mice and wild-type controls for genes involved in microglia and astrocyte function, cytokine and inflammatory signaling,

SUBMITTER: Lambracht-Washington D 

PROVIDER: S-EPMC7845550 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature