Novel Immune Modulators Enhance Caenorhabditis elegans Resistance to Multiple Pathogens.

ABSTRACT: Traditionally, treatments for bacterial infection have focused on killing the microbe or preventing its growth. As antimicrobial resistance becomes more ubiquitous, the feasibility of this approach is beginning to wane and attention has begun to shift toward disrupting the host-pathogen interaction by improving the host defense. Using a high-throughput, fragment-based screen to identify compounds that alleviate Pseudomonas aeruginosa-mediated killing of Caenorhabditis elegans, we identified over 20 compounds that stimulated host defense gene expression. Five of these molecules were selected for further characterization. Four of five compounds showed little toxicity against mammalian cells or worms, consistent with their identification in a phenotypic, high-content screen. Eac

SUBMITTER: Hummell NA 

PROVIDER: S-EPMC7845594 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature