Staphylococcus aureus Tolerance and Genomic Response to Photodynamic Inactivation.

ABSTRACT: Staphylococcus aureus is an opportunistic pathogen with a clinical spectrum ranging from asymptomatic skin colonization to invasive infections. While traditional antibiotic therapies can be effective against S. aureus, the increasing prevalence of antibiotic-resistant strains results in treatment failures and high mortality rates. Photodynamic inactivation (PDI) is an innovative and promising alternative to antibiotics. While progress has been made in our understanding of the bacterial response to PDI, major gaps remain in our knowledge of PDI tolerance, the global cellular response, and adaptive genomic mutations acquired as a result of PDI. To address these gaps, S. aureus HG003 and isogenic mutants with mutations in agr, mutS, mutL, and mutY<

SUBMITTER: Snell SB 

PROVIDER: S-EPMC7845598 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature