Biogeography of the Relationship between the Child Gut Microbiome and Innate Immune System.

ABSTRACT: The gut microbiome is a well-recognized modulator of host immunity, and its compositions differ between geographically separated human populations. Systemic innate immune responses to microbial derivatives also differ between geographically distinct human populations. However, the potential role of the microbiome in mediating geographically varied immune responses is unexplored. We here applied 16S amplicon sequencing to profile the stool microbiome and, in parallel, measured whole-blood innate immune cytokine responses to several pattern recognition receptor (PRR) agonists among 2-year-old children across biogeographically diverse settings. Microbiomes differed mainly between high- and low-resource environments and were not strongly associated with other demographic factors. We found stro

SUBMITTER: Amenyogbe N 

PROVIDER: S-EPMC7845628 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature