Disease-driven reduction in human mobility influences human-mosquito contacts and dengue transmission dynamics.

ABSTRACT: Heterogeneous exposure to mosquitoes determines an individual's contribution to vector-borne pathogen transmission. Particularly for dengue virus (DENV), there is a major difficulty in quantifying human-vector contacts due to the unknown coupled effect of key heterogeneities. To test the hypothesis that the reduction of human out-of-home mobility due to dengue illness will significantly influence population-level dynamics and the structure of DENV transmission chains, we extended an existing modeling framework to include social structure, disease-driven mobility reductions, and heterogeneous transmissibility from different infectious groups. Compared to a baseline model, naïve to human pre-symptomatic infectiousness and disease-driven mobility changes, a model including both parameters pre

SUBMITTER: Schaber KL 

PROVIDER: S-EPMC7845972 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature