Epigenetic suppression of SLFN11 in germinal center B-cells during B-cell development.

ABSTRACT:

Background

SLFN11 has recently been reported to execute cancer cells harboring replicative stress induced by DNA damaging agents. However, the roles of SLFN11 under physiological conditions remain poorly understood. Germinal center B-cells (GCBs) undergo somatic hypermutations and class-switch recombination, which can cause physiological genotoxic stress. Hence, we tested whether SLFN11 expression needs to be suppressed in GCBs during B-cell development.

Objective

To clarify the expression profile of SLFN11 in different developmental stages of B-cells and B-cell-derived cancers.

Methods

We analyzed the expression of SLFN11 by mining cell line databases for different stages of normal B-cells and various types of B-cell-derived cancer cell lines. We performed dual immun

SUBMITTER: Moribe F 

PROVIDER: S-EPMC7846023 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature