Breast cancer is marked by specific, Public T-cell receptor CDR3 regions shared by mice and humans.

ABSTRACT: The partial success of tumor immunotherapy induced by checkpoint blockade, which is not antigen-specific, suggests that the immune system of some patients contain antigen receptors able to specifically identify tumor cells. Here we focused on T-cell receptor (TCR) repertoires associated with spontaneous breast cancer. We studied the alpha and beta chain CDR3 domains of TCR repertoires of CD4 T cells using deep sequencing of cell populations in mice and applied the results to published TCR sequence data obtained from human patients. We screened peripheral blood T cells obtained monthly from individual mice spontaneously developing breast tumors by 5 months. We then looked at identical TCR sequences in published human studies; we used TCGA data from tumors and healthy tissues of 1,256 breast

SUBMITTER: Gordin M 

PROVIDER: S-EPMC7846026 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature