The Genetic Architecture of Emerging Fungicide Resistance in Populations of a Global Wheat Pathogen.

ABSTRACT: Containing fungal diseases often depends on the application of fungicidal compounds. Fungicides can rapidly lose effectiveness due to the rise of resistant individuals in populations. However, the lack of knowledge about resistance mutations beyond known target genes challenges investigations into pathways to resistance. We used whole-genome sequencing data and association mapping to reveal the multilocus genetic architecture of fungicide resistance in a global panel of 159 isolates of Parastagonospora nodorum, an important fungal pathogen of wheat. We found significant differences in azole resistance among global field populations. The populations evolved distinctive combinations of resistance alleles which can interact when co-occurring in the same genetic background. We identified 34 si

SUBMITTER: Pereira D 

PROVIDER: S-EPMC7846115 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature