European genetic ancestry associated with risk of childhood ependymoma.

ABSTRACT:

Background

Ependymoma is a histologically defined central nervous system tumor most commonly occurring in childhood. Population-level incidence differences by race/ethnicity are observed, with individuals of European ancestry at highest risk. We aimed to determine whether extent of European genetic ancestry is associated with ependymoma risk in US populations.

Methods

In a multi-ethnic study of Californian children (327 cases, 1970 controls), we estimated the proportions of European, African, and Native American ancestry among recently admixed Hispanic and African American subjects and estimated European admixture among non-Hispanic white subjects using genome-wide data. We tested whether genome-wide ancestry differences were associated with ependymoma risk and performed adm

SUBMITTER: Zhang C 

PROVIDER: S-EPMC7846152 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature