Adipose saturation reduces lipotoxic systemic inflammation and explains the obesity paradox.

ABSTRACT: Obesity sometimes seems protective in disease. This obesity paradox is predominantly described in reports from the Western Hemisphere during acute illnesses. Since adipose triglyceride composition corresponds to long-term dietary patterns, we performed a meta-analysis modeling the effect of obesity on severity of acute pancreatitis, in the context of dietary patterns of the countries from which the studies originated. Increased severity was noted in leaner populations with a higher proportion of unsaturated fat intake. In mice, greater hydrolysis of unsaturated visceral triglyceride caused worse organ failure during pancreatitis, even when the mice were leaner than those having saturated triglyceride. Saturation interfered with triglyceride's interaction and lipolysis by pancreatic triglyc

SUBMITTER: Khatua B 

PROVIDER: S-EPMC7846167 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature