Radiation-induced eosinophils improve cytotoxic T lymphocyte recruitment and response to immunotherapy.

ABSTRACT: The efficacy of cancer immunotherapy is dictated by CD8⁺ T cell infiltration and the nature of the tumor microenvironment (TME). By inflaming the TME to favor CD8⁺ T cell immunity, radiation is now widely considered as a neoadjuvant for immunomodulation. Here, we observed that local irradiation enhances the infiltration of intratumoral eosinophils, and depletion of eosinophil dampens CD8⁺ T cell infiltration and diminishes the anti-tumor effectiveness of radiation. Retrospectively, we identified a strong correlation between eosinophilia and survival benefit in radiation-treated cancer patients. Experimentally, we further show that radiation enhances the intratumoral infiltration of adoptive transferred T cells therapy, bolstering eosinophils by intravenous

SUBMITTER: Cheng JN 

PROVIDER: S-EPMC7846170 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature