Extensive tissue-specific expression variation and novel regulators underlying circadian behavior.

ABSTRACT: Natural genetic variation affects circadian rhythms across the evolutionary tree, but the underlying molecular mechanisms are poorly understood. We investigated population-level, molecular circadian clock variation by generating >700 tissue-specific transcriptomes of Drosophila melanogaster (w¹¹¹⁸ ) and 141 Drosophila Genetic Reference Panel (DGRP) lines. This comprehensive circadian gene expression atlas contains >1700 cycling genes including previously unknown central circadian clock components and tissue-specific regulators. Furthermore, >30% of DGRP lines exhibited aberrant circadian gene expression, revealing abundant genetic variation-mediated, intertissue circadian expression desynchrony. Genetic analysis of one line with the strongest deviating circa

SUBMITTER: Litovchenko M 

PROVIDER: S-EPMC7846174 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature