Cerebral atrophy in amyotrophic lateral sclerosis parallels the pathological distribution of TDP43.

ABSTRACT: Amyotrophic lateral sclerosis is a neurodegenerative disease characterized by a preferential involvement of both upper and lower motor neurons. Evidence from neuroimaging and post-mortem studies confirms additional involvement of brain regions extending beyond the motor cortex. The aim of this study was to assess the extent of cerebral disease in amyotrophic lateral sclerosis cross-sectionally and longitudinally and to compare the findings with a recently proposed disease-staging model of amyotrophic lateral sclerosis pathology. Deformation-based morphometry was used to identify the patterns of brain atrophy associated with amyotrophic lateral sclerosis and to assess their relationship with clinical symptoms. Longitudinal T₁-weighted MRI data and clinical measures were acquired

SUBMITTER: Dadar M 

PROVIDER: S-EPMC7846188 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature