Leveraging the antiviral type I interferon system as a first line of defense against SARS-CoV-2 pathogenicity.

ABSTRACT: The emergence and spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in significant global morbidity, mortality, and societal disruption. A better understanding of virus-host interactions may potentiate therapeutic insights toward limiting this infection. Here we investigated the dynamics of the systemic response to SARS-CoV-2 in hamsters by histological analysis and transcriptional profiling. Infection resulted in consistently high levels of virus in the upper and lower respiratory tracts and sporadic occurrence in other distal tissues. A longitudinal cohort revealed a wave of inflammation, including a type I interferon (IFN-I) response, that was evident in all tissues regardless of viral presence but was insufficient to prevent disease progression. Bolste

SUBMITTER: Hoagland DA 

PROVIDER: S-EPMC7846242 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature