Nanoengineered shear-thinning and bioprintable hydrogel as a versatile platform for biomedical applications.

ABSTRACT: The development of bioinks based on shear-thinning and self-healing hydrogels has recently attracted significant attention for constructing complex three-dimensional physiological microenvironments. For extrusion-based bioprinting, it is challenging to provide high structural reliability and resolution of printed structures while protecting cells from shear forces during printing. Herein, we present shear-thinning and printable hydrogels based on silicate nanomaterials, laponite (LA), and glycosaminoglycan nanoparticles (GAGNPs) for bioprinting applications. Nanocomposite hydrogels (GLgels) were rapidly formed within seconds due to the interactions between the negatively charged groups of GAGNPs and the edges of LA. The shear-thinning behavior of the hydrogel protected encapsulated cells f

SUBMITTER: Zandi N 

PROVIDER: S-EPMC7846391 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature