Human serum activates the tegument of female schistosomes and supports recovery from Praziquantel.

ABSTRACT: Schistosomiasis is one of the most devastating parasitic disease in the world. Schistosoma spp. survive for decades within the vasculature of their human hosts. They have evolved a vast array of mechanisms to avoid the immune reaction of the host. Due to their sexual dimorphism, with the female worm lying within the gynecophoric canal of the male worm, it is the male that is exposed to the immediate environment and the soluble parts of the host's immune response. To understand how the worms are so successful in fending off the immune attacks of the host, comparative analyses of both worm sexes in human serum (with or without Praziquantel) were performed using scanning electron microscopy, transmission electron microscopy, and immunohistochemistry. Further, gene expression analyses of tegum

SUBMITTER: Winkelmann F 

PROVIDER: S-EPMC7846515 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature