Cost-effectiveness of scaling up short course preventive therapy for tuberculosis among children across 12 countries.

ABSTRACT:

Background

While household contact investigation is widely recommended as a means to reduce the burden of tuberculosis (TB) among children, only 27% of eligible pediatric household contacts globally received preventive treatment in 2018. We assessed the cost-effectiveness of household contact investigation for TB treatment and short-course preventive therapy provision for children under 15 years old across 12 high TB burden countries.

Methods

We used decision analysis to compare the costs and estimated effectiveness of three intervention scenarios: (a) status quo (existing levels of coverage with isoniazid preventive therapy), (b) contact investigation with treatment of active TB but no additional preventive therapy, and (c) contact investigation with TB treatment and provis

SUBMITTER: Jo Y 

PROVIDER: S-EPMC7846666 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature