Survival of hypoxia-induced dormancy is not a common feature of all strains of the Mycobacterium tuberculosis complex.

ABSTRACT: While persistence in a dormant state is crucial for the life cycle of Mycobacterium tuberculosis, no investigation regarding dormancy survival of different strains across different lineages was performed so far. We analyzed responses to oxygen starvation and recovery in terms of growth, metabolism, and transcription. All different strains belonging to the Euro-American lineage (L4) showed similar survival and resuscitation characteristics. Different clinical isolates from the Beijing (L2), East African-Indian (L3), and Delhi/Central Asian (L1) lineage did not survive oxygen starvation. We show that dormancy survival is lineage-dependent. Recovery from O₂ starvation was only observed in strains belonging to the Euro-American (L4) lineage but not in strains belonging to different

SUBMITTER: Tizzano B 

PROVIDER: S-EPMC7846770 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature