Ontology highlight
ABSTRACT:
SUBMITTER: Nerli S
PROVIDER: S-EPMC7846771 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Nature communications 20210129 1
Methyl-specific isotope labeling is a powerful tool to study the structure, dynamics and interactions of large proteins and protein complexes by solution-state NMR. However, widespread applications of this methodology have been limited by challenges in obtaining confident resonance assignments. Here, we present Methyl Assignments Using Satisfiability (MAUS), leveraging Nuclear Overhauser Effect cross-peak data, peak residue type classification and a known 3D structure or structural model to prov ...[more]