Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions.

ABSTRACT: Low back pain (LBP), as a leading cause of disability, is a common musculoskeletal disorder that results in major social and economic burdens. Recent research has identified inflammation and related signaling pathways as important factors in the onset and progression of disc degeneration, a significant contributor to LBP. Inflammatory mediators also play an indispensable role in discogenic LBP. The suppression of LBP is a primary goal of clinical practice but has not received enough attention in disc research studies. Here, an overview of the advances in inflammation-related pain in disc degeneration is provided, with a discussion on the role of inflammation in IVD degeneration and pain induction. Puncture models, mechanical models, and spontaneous models as the main animal models to study

SUBMITTER: Lyu FJ 

PROVIDER: S-EPMC7846842 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature