Linking the oral microbiome and salivary cytokine abundance to circadian oscillations.

ABSTRACT: Saliva has immense potential as a diagnostic fluid for identification and monitoring of several systemic diseases. Composition of the microbiome and inflammation has been associated and reflective of oral and overall health. In addition, the relative ease of collection of saliva further strengthens large-scale diagnostic purposes. However, the future clinical utility of saliva cannot be fully determined without a detailed examination of daily fluctuations that may occur within the oral microbiome and inflammation due to circadian rhythm. In this study, we explored the association between the salivary microbiome and the concentration of IL-1β, IL-6 and IL-8 in the saliva of 12 healthy adults over a period of 24 h by studying the 16S rRNA gene followed by negative binomial mixed model regres

SUBMITTER: Sarkar A 

PROVIDER: S-EPMC7846843 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature