Gene expression profiling for the diagnosis of multiple primary malignant tumors.

ABSTRACT:

Background

The incidence of multiple primary malignant tumors (MPMTs) is rising due to the development of screening technologies, significant treatment advances and increased aging of the population. For patients with a prior cancer history, identifying the tumor origin of the second malignant lesion has important prognostic and therapeutic implications and still represents a difficult problem in clinical practice.

Methods

In this study, we evaluated the performance of a 90-gene expression assay and explored its potential diagnostic utility for MPMTs across a broad spectrum of tumor types. Thirty-five MPMT patients from Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University and Fudan University Shanghai Cancer Center were enrolled; 73 MPMT specimens met all qual

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC7846996 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature