Adipose-derived cellular therapies prolong graft survival in an allogenic hind limb transplantation model.

ABSTRACT:

Background

The long-term survival after vascularized composite allotransplantation (VCA) is often limited by systemic rejection as well as the adverse effects of immunosuppressants. The stromal vascular fraction (SVF) can be expanded to produce adipose-derived stem cells (ADSC) which represents a combination of endothelial cells, preadipocytes, immune cells, and ADSC. It has been demonstrated that ADSC possess consistently reliable clinical results. However, literature is scarce regarding SVF in VCA. This study seeks to determine the impact of ex vivo allograft pretreatment in combination with SVF cells in the ability to promote composite tissue allotransplantation immunotolerance.

Methods

A rat hind limb allotransplant model was used to investigate the influence of ex vivo

SUBMITTER: Chen J 

PROVIDER: S-EPMC7847016 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature