Pharmacokinetics and dialytic clearance of apixaban during in vitro continuous renal replacement therapy.

ABSTRACT:

Background

To evaluate the transmembrane clearance (CL_TM) of apixaban during modeled in vitro continuous renal replacement therapy (CRRT), assess protein binding and circuit adsorption, and provide initial dosing recommendations.

Methods

Apixaban was added to the CRRT circuit and serial pre-filter bovine blood samples were collected along with post-filter blood and effluent samples. All experiments were performed in duplicate using continuous veno-venous hemofiltration (CVVH) and hemodialysis (CVVHD) modes, with varying filter types, flow rates, and point of CVVH replacement fluid dilution. Concentrations of apixaban and urea were quantified via liquid chromatography-tandem mass spectrometry. Plasma pharmacokinetic parameters for apixaban were estimated via noncom

SUBMITTER: Andrews L 

PROVIDER: S-EPMC7847018 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature