Age-dependent changes of gender disparities in nasopharyngeal carcinoma survival.

ABSTRACT:

Background

The mortality of nasopharyngeal carcinoma (NPC) is usually lower in females than in males, but the underlying mechanism remains largely unknown. We sought to describe the age-dependent patterns of gender disparities in NPC survival and explore the extent to which the confounder or mediation effects could explain these differences.

Methods

A total of 11,980 patients with NPC were reviewed. The effect of gender on cancer-specific survival (CSS) was assessed using Cox regression analyses. Two propensity score methods were conducted to control the confounding bias between genders. Restricted cubic spline regression was used to model the association of gender and age with mortality flexibly. Multiple mediation analysis was applied to estimate the direct or indirect eff

SUBMITTER: Li WZ 

PROVIDER: S-EPMC7847041 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature