Effects of Stereochemistry and Hydrogen Bonding on Glycopolymer-Amyloid-β Interactions.

ABSTRACT: Saccharide stereochemistry plays an important role in carbohydrate functions such as biological recognition processes and protein binding. Synthetic glycopolymers with pendant saccharides of controlled stereochemistry provide an attractive approach for the design of polysaccharide-inspired biomaterials. Acrylamide-based polymers containing either β,d-glucose or β,d-galactose pendant groups, designed to mimic GM1 ganglioside saccharides, and their small-molecule analogues were used to evaluate the effect of stereochemistry on glycopolymer solution aggregation processes alone and in the presence of Aβ42 peptide using dynamic light scattering, gel permeation chromatography-multiangle laser light scattering, and fluorescence assays. Fourier transform infrared and nuclear magnetic resonance (NM

SUBMITTER: Bristol AN 

PROVIDER: S-EPMC7847044 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature