Migratory CD11b⁺ conventional dendritic cells induce T follicular helper cell-dependent antibody responses.

ABSTRACT: T follicular helper (Tfh) cells are a subset of CD4⁺ T cells that promote antibody production during vaccination. Conventional dendritic cells (cDCs) efficiently prime Tfh cells; however, conclusions regarding which cDC instructs Tfh cell differentiation have differed between recent studies. We found that these discrepancies might exist because of the unusual sites used for immunization in murine models, which differentially bias which DC subsets access antigen. We used intranasal immunization as a physiologically relevant route of exposure that delivers antigen to all tissue DC subsets. Using a combination of mice in which the function of individual DC subsets is impaired and different antigen formulations, we determined that CD11b⁺ migratory type 2 cDCs (cDC2s) are

SUBMITTER: Krishnaswamy JK 

PROVIDER: S-EPMC7847246 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature