Hypertension, antihypertensive medications use and risk of age-related macular degeneration in California Teachers Cohort.

ABSTRACT: Sustained and inadequately controlled hypertension can promote the development of age-related macular degeneration (AMD) through multiple biologic pathways. Epidemiologic studies of high blood pressure, antihypertensive therapies, and the risk of AMD thus far have been inconclusive. However, few studies evaluated risks according to the use of different classes of antihypertensive drugs or took combinations of use into account. We performed a prospective cohort study by linking the California Teachers Study (CTS) cohort (N = 88 481) to statewide hospital discharge records up to December 31, 2012. History of high blood pressure, regular use of antihypertensive medications, and comprehensive risk factor information was collected via self-administered questionnaires at baseline in 1995-1996, a

SUBMITTER: Xu X 

PROVIDER: S-EPMC7847248 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature